Article
Copper toxicosis in Bedlington terriers is associated with multiple independent genetic variants.
The Veterinary record - 1 Jan 2000
Haywood Susan, Swinburne June, Schofield Ellen, Constantino-Casas Fernando, Watson Penny
Abstract excerpt
BACKGROUND: Bedlington terrier copper toxicosis (CT) is due to a homozygous exon deletion in COMMD1. CT also occurs in Bedlingtons lacking this deletion. An association with two ABCA12 single nuceotide polymorphism (SNP) splice variants was reported. Labrador retriever CT is associated with a missense mutation in ATP7B, and with a protective mutation in ATP7A. METHODS: Liver and DNA samples from 24 affected and...
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