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Article

Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients.

Journal of molecular medicine (Berlin, Germany) - 1 Sept 2004

Stuehler Bettina, Reichert Juergen, Stremmel Wolfgang, Schaefer Mark

Abstract excerpt

Wilson disease is a human disorder of copper metabolism resulting in toxic copper accumulation. Patients present with a high clinical variability, even when sharing identical mutations. MURR1, the gene causing canine copper toxicosis in Bedlington terriers, maps to chromosome 2 in humans, a region different to the Wilson gene locus. MURR1 might influence human copper metabolism and the clinical presentation of...

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Identifiers

PMID: 15205742
DOI: 10.1007/s00109-004-0557-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients.PMID 15205742Read ↗

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The canine copper toxicosis gene MURR1 is not implicated in the pathogenesis of Wilson disease.Semantic proximity Read ↗

The Copper Toxicosis Gene Product Murr1 Directly Interacts with the Wilson Disease ProteinSemantic proximity Read ↗

Copper toxicosis gene MURR1 is not changed in Wilson disease patients with normal blood ceruloplasmin levels.Semantic proximity Read ↗

Indirect molecular diagnosis of copper toxicosis in Bedlington terriers is complicated by haplotype diversity.Semantic proximity Read ↗

Identification of a new copper metabolism gene by positional cloning in a purebred dog populationSemantic proximity Read ↗

Characterization of the COMMD1 (MURR1) mutation causing copper toxicosis in Bedlington terriers.Semantic proximity Read ↗

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