Article
Transforming growth factor beta-1 -509C>T polymorphism in Indian patients with primary open angle glaucoma.
Molecular diagnosis & therapy - 1 Jan 2007
Sripriya Sarangapani, George Ronnie, Arvind Hemamalini, Baskaran Mani, Raju Prema, Ramesh S V, Karthiyayini Tirumalai, Vijaya Lingam, Kumaramanickavel Govindasamy
Abstract excerpt
BACKGROUND: Extracellular matrix (ECM) accumulation in the trabecular meshwork tissues of glaucoma patients has been demonstrated as one of the factors that contribute to glaucoma pathology. Transforming growth factor-beta (TGFbeta) has its fundamental function in regulating the ECM molecules and has been implicated in glaucoma pathology. In this study, the association of the TGFB1-509C>T single nucleotide...
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