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Article

Genetic association of -1562C>T polymorphism in the MMP9 gene with primary glaucoma in a north Indian population.

PloS one - 1 Jan 2018

Thakur Nanamika, Kupani Manu, Pandey Rajeev Kumar, Mannan Rashim, Pruthi Archna, Mehrotra Sanjana

Abstract excerpt

MMP (Matrix metalloproteinase) 9 is reported to affect glaucoma pathogenesis by altering intraocular pressure (IOP) through its role in remodeling the extracellular matrix (ECM) in the trabecular meshwork. A genetic variant at the promoter region in the MMP9 gene (-1562C>T) has a putative role in regulating its transcription rate and hence can affect genetic predisposition to primary glaucoma. The present study...

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Source

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Identifiers

PMID: 29432439
DOI: 10.1371/journal.pone.0192636
PMCID: PMC5809065

Genes

MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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