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Article

Suggestive evidence of male specific genetic association of IL8 -251T>A promoter polymorphism with primary angle closure glaucoma in a north Indian Punjabi population.

BMC ophthalmology - 2 Dec 2024

Thakur Nanamika, Pandey Rajeev Kumar, Vig Vipin Kumar, Mehrotra Sanjana

Abstract excerpt

BACKGROUND: Overproduction of IL-8 in the retina and optic nerve may affect the survival of retinal ganglion cells (RGCs) and contribute to axonal damage in glaucoma. The -251T > A functional variant in the promoter region of the IL8 gene is known to affect its transcriptional activity, as demonstrated in in vitro assays. METHODS: The present study investigates the genetic association of this polymorphism with...

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Case-Control Studies
Glaucoma, Angle-Closure
Glaucoma, Open-Angle
India
Interleukin-8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Restriction Fragment Length

Promoter Regions, Genetic

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Identifiers

PMID: 39623324
DOI: 10.1186/s12886-024-03786-y
PMCID: PMC11610091

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