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Article

Hypermethylation of apoptotic genes as independent prognostic factor in neuroblastoma disease

23 Nov 2010

Abstract excerpt

Neuroblastoma (NB) is an embryonal tumour of neuroectodermal cells, and its prognosis is based on patient age at diagnosis, tumour stage and MYCN amplification, but it can also be classified according to their degree of methylation. Considering that epigenetic aberrations could influence patient survival, we studied the methylation status of a series of 17 genes functionally involved in different cellular...

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PMID: 21104989
DOI: 10.1002/mc.20700

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