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Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma

11 Feb 2011

Abstract excerpt

BACKGROUND: Epigenetic mechanisms such as DNA methylation and histone modifications are important regulators of gene expression and are frequently involved in silencing tumor suppressor genes. METHODS: In order to identify genes that are epigenetically regulated in neuroblastoma tumors, we treated four neuroblastoma cell lines with the demethylating agent 5-Aza-2'-deoxycytidine (5-Aza-dC) either separately or in...

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PMID: 21314941
DOI: 10.1186/1471-2407-11-66

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