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Article

RASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients: a prognostic marker

1 Jan 2009

Abstract excerpt

The tumour suppressor gene RASSF1A is known to be frequently silenced by promoter hypermethylation in neuroblastoma tumours. Here we explored the possible prognostic significance of aberrant promoter hypermethylation of RASSF1A in serum DNA samples of patients with neuroblastoma as a surrogate marker for circulating tumour cells. We analysed the methylation status of the RASSF1A gene in matched tumour and...

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PMID: 19165202
DOI: 10.1038/sj.bjc.6604887

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