Article
Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy.
Heart (British Cardiac Society) - 1 Jul 2007
Barbato Emanuele, Penicka Martin, Delrue Leen, Van Durme Frederic, De Bruyne Bernard, Goethals Marc, Wijns William, Vanderheyden Marc, Bartunek Jozef
Abstract excerpt
BACKGROUND: Beta2-adrenergic receptor Thr164Ile (threonine (Thr) is replaced by an isoleucine (Ile) at codon 164) polymorphism was postulated to contribute to lower exercise tolerance and poor prognosis in patients with congestive heart failure. However, heart failure is associated with several abnormalities of beta receptor signalling, and underlying mechanisms are not clear. OBJECTIVES: To investigate whether...
Topics
- Adrenergic beta-Agonists
- Blood Pressure
- Cardiomyopathy, Dilated
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Myocardial Contraction
- Polymorphism, Genetic