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Article

Quantitative trait locus analysis reveals two intragenic sites that influence O6-alkylguanine-DNA alkyltransferase activity in peripheral blood mononuclear cells.

Carcinogenesis - 1 Aug 2005

Margison Geoffrey P, Heighway Jim, Pearson Steven, McGown Gail, Thorncroft Mary R, Watson Amanda J, Harrison Kathryn L, Lewis Sarah J, Rohde Klaus, Barber Philip V, O'Donnell Paul, Povey Andrew C, Santibáñez-Koref Mauro F

Abstract excerpt

The repair of specific types of DNA alkylation damage by O6-alkylguanine-DNA alkyltransferase (MGMT) is a major mechanism of resistance to the carcinogenic and chemotherapeutic effects of certain alkylating agents. MGMT expression levels vary widely between individuals but the underlying causes of this variability are not known. To address this, we used an expressed single nucleotide polymorphism (SNP) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15831531
DOI: 10.1093/carcin/bgi087

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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