Article
Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.
Diabetes - 1 Dec 1991
Choi W H, O'Rahilly S, Buse J B, Rees A, Morgan R, Flier J S, Moller D E
Abstract excerpt
We investigated the prevalence of mutations in the gene encoding the major insulin-responsive facilitative glucose transporter (GLUT4) in patients with non-insulin-dependent diabetes mellitus (NIDDM). All 11 exons of the GLUT4 gene from 30 British white subjects with NIDDM were amplified using the polymerase chain reaction and screened for nucleotide sequence variation using the single-stranded conformation...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Codon
- DNA
- Diabetes Mellitus, Type 2
- Exons
- Genes
- Genetic Variation
- Humans
- Insulin
- Molecular Sequence Data