Article
Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients.
Diabetologia - 1 Apr 1994
Tanizawa Y, Riggs A C, Chiu K C, Janssen R C, Bell D S, Go R P, Roseman J M, Acton R T, Permutt M A
Abstract excerpt
The purpose of these experiments was to test the hypothesis that impaired glucose-stimulated insulin secretion in NIDDM is due to mutations in the islet beta cell/liver glucose transporter (GLUT 2) gene. Using oligonucleotide primers flanking each of the 11 exons, the structural portion of the gene was studied by PCR-SSCP analysis. DNA from African-American females (n = 48), who had gestational diabetes but...
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