Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.

doi:10.1007/BF02342449

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Article

Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.

Diabetologia - 1 May 1992

O'Rahilly S, Krook A, Morgan R, Rees A, Flier J S, Moller D E

Abstract excerpt

We have recently examined the exons encoding the insulin receptor tyrosine kinase domain and GLUT 4 in 30 subjects with Type 2 (non-insulin-dependent) diabetes mellitus using a molecular scanning approach. The variant sequences Val-Met985 and Lys-Glu1068 of the insulin receptor and Val-Ile383 of GLUT 4 were each separately found in three different diabetic subjects. In a study of a Welsh population, the GLUT...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Codon
Diabetes Mellitus, Type 2
Genetic Variation
Humans
Middle Aged
Molecular Sequence Data
Monosaccharide Transport Proteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Receptor, Insulin

Reference Values

Restriction Mapping

Wales

Source

Open in PubMed

Identifiers

PMID: 1521731
DOI: 10.1007/BF02342449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1521731-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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