A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

doi:10.1002/j.1460-2075.1991.tb04979.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

The EMBO journal - 1 Dec 1991

Hancock J F, Cadwallader K, Paterson H, Marshall C J

Abstract excerpt

Mutational analysis of p21ras has shown that plasma membrane targeting requires the combination of a CAAX motif with a polybasic domain of six lysine residues or a nearby palmitoylation site. However, it is not known from these studies whether these signals alone target p21ras to the plasma membrane. We now show that these C-terminal sequences are sufficient to target a heterologous cytosolic protein to the...

Topics

3T3 Cells
Animals
Base Sequence
Biological Transport
Blotting, Western
Cell Line
Cell Membrane
Dogs
Fluorescent Antibody Technique
Kidney
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Protein p21(ras)

Plasmids

Protein Biosynthesis

Protein Sorting Signals

Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 1756714
DOI: 10.1002/j.1460-2075.1991.tb04979.x
PMCID: PMC453151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1756714-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.PMID 1756714Read ↗

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane.Semantic proximity Read ↗

Novel determinants of H-Ras plasma membrane localization and transformation.Semantic proximity Read ↗

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.Semantic proximity Read ↗

Farnesylation and proteolysis are sequential, but distinct steps in the CaaX box modification pathway.Semantic proximity Read ↗

Palmitoylation of oncogenic NRAS is essential for leukemogenesisSemantic proximity Read ↗

Functional roles for fatty acylated amino-terminal domains in subcellular localization.Semantic proximity Read ↗

The p21 ras C-terminus is required for transformation and membrane association.Semantic proximity Read ↗

Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling.Semantic proximity Read ↗

Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway.Semantic proximity Read ↗

Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.Semantic proximity Read ↗

Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.Semantic proximity Read ↗

Myristoylation is required for the intracellular localization and endocytic function of ARF6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.