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Article

Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity.

The Journal of biological chemistry - 24 Aug 2007

Qi Jie, Forgac Michael

Abstract excerpt

One mechanism of regulating V-ATPase activity in vivo involves reversible dissociation into its component V(1) and V(0) domains, which in yeast occurs in response to glucose depletion. V-ATPase complexes containing the Vph1p isoform of subunit a (VCC) are targeted to the vacuole, and Stv1p-containing complexes (SCC) are targeted to the Golgi. Overexpression of Stv1p results in mistargeting of SCC to the vacuole....

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PMID: 17565997
DOI: 10.1074/jbc.M700663200
PMCID: PMC2394669

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