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Article

The Ras/cAMP/protein kinase A pathway regulates glucose-dependent assembly of the vacuolar (H+)-ATPase in yeast.

The Journal of biological chemistry - 26 Dec 2008

Bond Sarah, Forgac Michael

Abstract excerpt

Vacuolar (H+)-ATPases (V-ATPases) are ubiquitous, ATP-driven proton pumps that acidify organelles or the extracellular space. A rapid and effective mechanism for regulating V-ATPase activity involves reversible dissociation of the two functional domains of the pump, V1 and V0. This process is best characterized in yeast, where V-ATPases are reversibly disassembled in response to glucose depletion. To identify...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18936098
DOI: 10.1074/jbc.M805232200
PMCID: PMC2605986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Ras/cAMP/protein kinase A pathway regulates glucose-dependent assembly of the vacuolar (H+)-ATPase in yeast.PMID 18936098Read ↗

Cellular environment is important in controlling V-ATPase dissociation and its dependence on activity.Semantic proximity Read ↗

Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast.Semantic proximity Read ↗

Interaction between the yeast RAVE complex and Vph1-containing Vo sectors is a central glucose-sensitive interaction required for V-ATPase reassembly.Semantic proximity Read ↗

Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeast.Semantic proximity Read ↗

The RAVE complex is essential for stable assembly of the yeast V-ATPase.Semantic proximity Read ↗

Compensatory Internalization of Pma1 in V-ATPase Mutants in Saccharomyces cerevisiae Requires Calcium- and Glucose-Sensitive Phosphatases.Semantic proximity Read ↗

V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging.Semantic proximity Read ↗

Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump.Semantic proximity Read ↗

V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative AgingSemantic proximity Read ↗

The tether connecting cytosolic (N terminus) and membrane (C terminus) domains of yeast V-ATPase subunit a (Vph1) is required for assembly of V0 subunit d.Semantic proximity Read ↗

The cell wall integrity/remodeling MAPK cascade is involved in glucose activation of the yeast plasma membrane H(+)-ATPase.Semantic proximity Read ↗

Degradation of the gluconeogenic enzyme fructose-1, 6-bisphosphatase is dependent on the vacuolar ATPase.Semantic proximity Read ↗

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