Article
Role of Vma21p in assembly and transport of the yeast vacuolar ATPase.
Molecular biology of the cell - 1 Nov 2004
Malkus Per, Graham Laurie A, Stevens Tom H, Schekman Randy
Abstract excerpt
The Saccharomyces cerevisiae vacuolar H+-ATPase (V-ATPase) is a multisubunit complex composed of a peripheral membrane sector (V1) responsible for ATP hydrolysis and an integral membrane sector (V0) required for proton translocation. Biogenesis of V0 requires an endoplasmic reticulum (ER)-localized accessory factor, Vma21p. We found that in vma21Delta cells, the major proteolipid subunit of V0 failed to interact...
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