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Article

The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase.

The Journal of biological chemistry - 15 Jul 1992

Manolson M F, Proteau D, Preston R A, Stenbit A, Roberts B T, Hoyt M A, Preuss D, Mulholland J, Botstein D, Jones E W

Abstract excerpt

Yeast vacuolar acidification-defective (vph) mutants were identified using the pH-sensitive fluorescence of 6-carboxyfluorescein diacetate (Preston, R. A., Murphy, R. F., and Jones, E. W. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 7027-7031). Vacuoles purified from yeast bearing the vph1-1 mutation had no detectable bafilomycin-sensitive ATPase activity or ATP-dependent proton pumping. The peripherally bound...

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PMID: 1385813

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