Article
The tether connecting cytosolic (N terminus) and membrane (C terminus) domains of yeast V-ATPase subunit a (Vph1) is required for assembly of V0 subunit d.
The Journal of biological chemistry - 17 Jul 2009
Ediger Benjamin, Melman Sandra D, Pappas Donald L, Finch Mark, Applen Jeremy, Parra Karlett J
Abstract excerpt
V-ATPases are molecular motors that reversibly disassemble in vivo. Anchored in the membrane is subunit a. Subunit a has a movable N terminus that switches positions during disassembly and reassembly. Deletions were made at residues securing the N terminus of subunit a (yeast isoform Vph1) to its membrane-bound C-terminal domain in order to understand the role of this conserved region for V-ATPase function....
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