Discrimination between defects in elongation fidelity and termination efficiency provides mechanistic insights into translational readthrough.

Abstract excerpt

The suppression of stop codons (termed translational readthrough) can be caused by a decreased accuracy of translation elongation or a reduced efficiency of translation termination. In previous studies, the inability to determine the extent to which each of these distinct processes contributes to a readthrough phenotype has limited our ability to evaluate how defects in the translational machinery influence the...

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