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Article

Investigation of the association between interleukin-1beta polymorphism and normal tension glaucoma.

Molecular vision - 14 May 2007

Wang Chun Yuan, Shen Ying-Cheng, Su Chien-Hui, Lo Fai-Yun, Lee Shi-Huang, Tsai Hin-Yeung, Fan Seng-Sheen

Abstract excerpt

PURPOSE: In normal tension glaucoma (NTG), factors other than elevated intraocular pressure are likely to have a role in the pathogenesis of optic neuropathy. The potential similarities in cellular apoptosis leading to neurodegeneration between Alzheimer's disease and NTG were shown in recent studies. The interleukin-1beta (IL-1beta; -511) and IL-1beta (+3953) polymorphisms were found to increase risk with...

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Identifiers

PMID: 17563722
PMCID: PMC2765469

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