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Article

Polymorphism in the TNF-α(-863) locus associated with reduced risk of primary open angle glaucoma.

Molecular vision - 1 Jan 2012

Wang Chun-Yuan, Shen Ying-Cheng, Wei Li-Chen, Lin Keng-Hung, Feng Shih-Chao, Yang Yi-Yin, Chiu Chun-Hung, Tsai Hin-Yeung

Abstract excerpt

PURPOSE: Tumor necrosis factor-α (TNF-α), an important proinflammatory cytokine, exerts a variety of physiologic and pathogenic effects that lead to tissue destruction. Recent laboratory evidence indicates that TNF-α have either protective or adverse effects on primary open angle glaucoma (POAG). Inheritance of the TNF-α (-863) C allele has been associated with an elevated risk of Alzheimer disease. The neuronal...

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Source

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Identifiers

PMID: 22509108
PMCID: PMC3324355

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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