Article
The variant N363S of glucocorticoid receptor in steroid-induced ocular hypertension in Hungarian patients treated with photorefractive keratectomy.
Molecular vision - 27 Apr 2007
Szabó Viktória, Borgulya Gábor, Filkorn Tamás, Majnik Judit, Bányász Ilona, Nagy Zoltán Zsolt
Abstract excerpt
PURPOSE: Variation in sensitivity to glucocorticoids observed in healthy population is influenced by genetic polymorphisms of the glucocorticoid receptor gene (NR3C1). N363S, ER22/23EK, and Bcl I have been previously described as glucocorticoid-sensitivity modulating polymorphisms. We investigated whether these variants may contribute to steroid-induced ocular hypertension and if they play a role as protective or...
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