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Article

Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment Epithelium

5 Sept 2021

Abstract excerpt

Glucocorticoids are amongst the most used drugs to treat retinal diseases of various origins. Yet, the transcriptional regulations induced by glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) activation in retinal pigment epithelium cells (RPE) that form the outer blood–retina barrier are unknown. Levels of endogenous corticoids, ligands for MR and GR, were measured in human ocular media. Human RPE...

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PMID: 34502527
DOI: 10.3390/ijms22179618

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