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Article

The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.

Current opinion in clinical nutrition and metabolic care - 1 Jul 2007

Tönjes Anke, Stumvoll Michael

Abstract excerpt

PURPOSE OF REVIEW: To provide a timely update of the literature regarding the role of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene in type 2 diabetes and related phenotypes. RECENT FINDINGS: The adipocyte-specific gamma2 isoform of peroxisome proliferator-activated receptor gamma is now considered to be one of the best-replicated genetic risk factors of common type 2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17563457
DOI: 10.1097/MCO.0b013e3281e389d9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.PMID 17563457Read ↗

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The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala PolymorphismSemantic proximity Read ↗

The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.Semantic proximity Read ↗

Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPARgamma-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population.Semantic proximity Read ↗

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.Semantic proximity Read ↗

The frequency of alleles of the Pro12Ala polymorphism in PPARgamma2 is different between healthy controls and patients with type 2 diabetes.Semantic proximity Read ↗

Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients.Semantic proximity Read ↗

Effects of Pro12Ala polymorphism in peroxisome proliferator-activated receptor-γ2 gene on metabolic syndrome risk: a meta-analysis.Semantic proximity Read ↗

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