Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients.

doi:10.1055/s-2002-23487

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Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association - 1 Apr 2002

Zietz B, Barth N, Spiegel D, Schmitz G, Schölmerich J, Schäffler A

Abstract excerpt

UNLABELLED: The peroxisome proliferator-activated receptor-gamma2 (PPAR(gamma2)) represents the transcriptional master regulator of adipocyte differentiation and therefore has been suggested as candidate gene for the pathogenesis of obesity, type 2 diabetes and related metabolic disorders. Aim of our study was to determine the frequency of a missense point mutation within exon 2 of PPAR(gamma2), Pro12Ala, and its...

Topics

Aged
Alanine
Alleles
Cholesterol
Cholesterol, LDL
Cohort Studies
Diabetes Mellitus, Type 2
Female
Heterozygote
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hypercholesterolemia

Logistic Models

Male

Middle Aged

Mutation

Polymerase Chain Reaction

Proline

Source

Open in PubMed

Identifiers

PMID: 11928067
DOI: 10.1055/s-2002-23487

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