The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.

doi:10.1038/79216

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.

Nature genetics - 1 Sept 2000

Altshuler D, Hirschhorn J N, Klannemark M, Lindgren C M, Vohl M C, Nemesh J, Lane C R, Schaffner S F, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson T J, Daly M, Groop L, Lander E S

Abstract excerpt

Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in multiple samples and with comprehensive controls. We evaluated 16 published genetic associations to type 2 diabetes and...

Topics

Adult
Age of Onset
Aged
Alanine
Alleles
Blood Glucose
Blood Pressure
Body Mass Index
Cholesterol
Diabetes Mellitus, Type 2
Family Health
Fathers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genotype

Humans

Linkage Disequilibrium

Lipoproteins, HDL

Male

Source

Open in PubMed

Identifiers

PMID: 10973253
DOI: 10.1038/79216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10973253-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.PMID 10973253Read ↗

The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis.Semantic proximity Read ↗

The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk.Semantic proximity Read ↗

The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala PolymorphismSemantic proximity Read ↗

The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences.Semantic proximity Read ↗

The frequency of alleles of the Pro12Ala polymorphism in PPARgamma2 is different between healthy controls and patients with type 2 diabetes.Semantic proximity Read ↗

The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.Semantic proximity Read ↗

Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.Semantic proximity Read ↗

Effect of the peroxisome proliferator-activated receptor-gamma 2 pro(12)ala variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds.Semantic proximity Read ↗

Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes.Semantic proximity Read ↗

The association between the Pro12Ala variant in the PPARγ2 gene and type 2 diabetes mellitus and obesity in a Chinese population.Semantic proximity Read ↗

A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians.Semantic proximity Read ↗

Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.