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Article

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.

Nature genetics - 1 Sept 2000

Altshuler D, Hirschhorn J N, Klannemark M, Lindgren C M, Vohl M C, Nemesh J, Lane C R, Schaffner S F, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson T J, Daly M, Groop L, Lander E S

Abstract excerpt

Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in multiple samples and with comprehensive controls. We evaluated 16 published genetic associations to type 2 diabetes and related sub-phenotypes using a family-based design to control for population stratification, and replication samples...

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PMID: 10973253
DOI: 10.1038/79216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.PMID 10973253Read ↗

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