Article
The Pro12Ala polymorphism of PPARgamma2 gene and susceptibility to type 2 diabetes mellitus in a Polish population.
Diabetes research and clinical practice - 1 Nov 2003
Malecki Maciej T, Frey Jakub, Klupa Tomasz, Skupien Jan, Walus Malgorzata, Mlynarski Wojciech, Sieradzki Jacek
Abstract excerpt
INTRODUCTION: It has recently been shown that polymorphisms of some genes might influence the genetic susceptibility to complex, multifactorial forms of type 2 diabetes mellitus (T2DM). One of those genes is peroxisome proliferator activated receptor gamma (PPARgamma). The PPARgamma gene product is a nuclear hormone receptor that regulates adipogenesis and is a target for thiazolidinediones, medications enhancing...
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