Article
Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor gamma2 gene in Iranian diabetic and obese subjects.
Metabolic syndrome and related disorders - 1 Oct 2009
Mirzaei Hassan, Akrami Seyed Mohammad, Golmohammadi Taghi, Doosti Mahmood, Heshmat Ramin, Nakhjavani Manouchehr, Amiri Parvin
Abstract excerpt
BACKGROUND: Peroxisome proliferator-activated receptor gamma2 (PPARgamma2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity. The aim of this study was to investigate the association between the Pro12Ala single nucleotide polymorphism (SNP) at the PPARgamma2 gene and type II diabetes (T2DM) and obesity in an Iranian population. METHODS: The genomic DNA of...
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