Article
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
The Journal of biological chemistry - 1 Jul 2005
Trakul Nicholas, Menard Raymond E, Schade George R, Qian Zhijian, Rosner Marsha Rich
Abstract excerpt
Raf kinase inhibitory protein (RKIP; also known as phosphatidylethanolamine-binding protein or PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. Here, we show that RKIP inhibits MAPK by regulating Raf-1 activation; specifically, RKIP acts subsequent to Raf-1 membrane recruitment, prevents association of Raf-1 and p21-activated kinase (PAK), and blocks phosphorylation of...
Topics
- Animals
- Aspartic Acid
- Cell Line
- Cell Membrane
- Cell Proliferation
- DNA
- Dose-Response Relationship, Drug
- Enzyme Activation
- Epidermal Growth Factor
- Epithelial Cells
- Growth Substances