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Article

Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.

The Journal of biological chemistry - 1 Jul 2005

Trakul Nicholas, Menard Raymond E, Schade George R, Qian Zhijian, Rosner Marsha Rich

Abstract excerpt

Raf kinase inhibitory protein (RKIP; also known as phosphatidylethanolamine-binding protein or PEBP) is a modulator of the Raf/MAPK signaling cascade and a suppressor of metastatic cancer. Here, we show that RKIP inhibits MAPK by regulating Raf-1 activation; specifically, RKIP acts subsequent to Raf-1 membrane recruitment, prevents association of Raf-1 and p21-activated kinase (PAK), and blocks phosphorylation of...

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Identifiers

PMID: 15886202
DOI: 10.1074/jbc.M413929200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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