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Article

Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.

Antimicrobial agents and chemotherapy - 1 Aug 2007

Nsobya Samuel L, Dokomajilar Christian, Joloba Moses, Dorsey Grant, Rosenthal Philip J

Abstract excerpt

Key parasite polymorphisms were assessed in subjects treated for malaria with artesunate-amodiaquine in Tororo, Uganda. For pfcrt, all of the isolates tested had the CVIET haplotype. For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine.

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Identifiers

PMID: 17562798
DOI: 10.1128/AAC.00012-07
PMCID: PMC1932488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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