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Article

Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children.

The Journal of infectious diseases - 1 Aug 2014

Conrad Melissa D, LeClair Norbert, Arinaitwe Emmanuel, Wanzira Humphrey, Kakuru Abel, Bigira Victor, Muhindo Mary, Kamya Moses R, Tappero Jordan W, Greenhouse Bryan, Dorsey Grant, Rosenthal Philip J

Abstract excerpt

BACKGROUND: Artemisinin-based combination therapies, including artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP), are recommended to treat uncomplicated falciparum malaria. Sensitivities to components of AL and DP are impacted by polymorphisms in pfmdr1 and pfcrt. We monitored changes in prevalences of polymorphisms in Tororo, Uganda, from 2008 to 2012. METHODS: Polymorphic loci in pfmdr1 and...

Topics

Alleles
Artemisinins
Child, Preschool
Drug Resistance
Female
Humans
Infant
Malaria, Falciparum
Male
Plasmodium falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Uganda

Source

Open in PubMed Open full text

Identifiers

PMID: 24610872
DOI: 10.1093/infdis/jiu141
PMCID: PMC4110461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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