Article
Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.
Neural development - 8 Jun 2007
Ma Lin, Cantrup Robert, Varrault Annie, Colak Dilek, Klenin Natalia, Götz Magdalena, McFarlane Sarah, Journot Laurent, Schuurmans Carol
Abstract excerpt
BACKGROUND: Organs are programmed to acquire a particular size during development, but the regulatory mechanisms that dictate when dividing progenitor cells should permanently exit the cell cycle and stop producing additional daughter cells are poorly understood. In differentiated tissues, tumor suppressor genes maintain a constant cell number and intact tissue architecture by controlling proliferation, apoptosis...
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