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Article

The transcription factor Maz is essential for normal eye development.

Disease models & mechanisms - 18 Aug 2020

Medina-Martinez Olga, Haller Meade, Rosenfeld Jill A, O'Neill Marisol A, Lamb Dolores J, Jamrich Milan

Abstract excerpt

Wnt/β-catenin signaling has an essential role in eye development. Faulty regulation of this pathway results in ocular malformations, owing to defects in cell-fate determination and differentiation. Herein, we show that disruption of Maz, the gene encoding Myc-associated zinc-finger transcription factor, produces developmental eye defects in mice and humans. Expression of key genes involved in the Wnt cascade,...

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Identifiers

PMID: 32571845
DOI: 10.1242/dmm.044412
PMCID: PMC7449797

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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