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Article

The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.

Cancer research - 15 Dec 2000

Pagotto U, Arzberger T, Theodoropoulou M, Grübler Y, Pantaloni C, Saeger W, Losa M, Journot L, Stalla G K, Spengler D

Abstract excerpt

The ZAC gene encodes a new zinc-finger protein that concomitantly induces apoptosis and cell cycle arrest and localizes to chromosome 6q24-q25, a well-known hot spot related to cancer. ZAC is highly expressed in the anterior pituitary gland, and its ablation by antisense targeting promotes pituit...

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Source

Identifiers

PMID: 11156367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11156367-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.PMID 11156367Read ↗

Inhibition of Zac1, a New Gene Differentially Expressed in the Anterior Pituitary, Increases Cell Proliferation*Semantic proximity Read ↗

Peroxisome Proliferator-Activated Receptor γ Is a Zac Target Gene Mediating Zac AntiproliferationSemantic proximity Read ↗

Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.Semantic proximity Read ↗

Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas.Semantic proximity Read ↗

<i>hZAC</i> encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancerSemantic proximity Read ↗

Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: differential phenotype of the Zac1-expressing cells during development.Semantic proximity Read ↗

Zac1 functional interactions mediate AP-1 transcriptional activity.Semantic proximity Read ↗

Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.Semantic proximity Read ↗

Members of the <i>Plag</i> gene family are expressed in complementary and overlapping regions in the developing murine nervous systemSemantic proximity Read ↗

Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus.Semantic proximity Read ↗

A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions.Semantic proximity Read ↗

Preferential loss of the nonimprinted allele for the ZAC1 tumor suppressor gene in human capillary hemangioblastoma.Semantic proximity Read ↗

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