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Article

Inhibition of Zac1, a New Gene Differentially Expressed in the Anterior Pituitary, Increases Cell Proliferation*

1 Feb 1999

Abstract excerpt

Zac1 is a new zinc finger protein that concomitantly controls apoptosis and cell cycle arrest through separate pathways. The mouse Zac1 gene is mainly expressed in the pituitary gland and in different brain areas. In this study regional and cellular expression of Zac1 in the pituitary gland was determined by in situ hybridization. Zac1 messenger RNA was abundantly expressed in the anterior pituitary lobe compared...

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Identifiers

PMID: 9927333
DOI: 10.1210/endo.140.2.6532

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Zac1, a New Gene Differentially Expressed in the Anterior Pituitary, Increases Cell Proliferation*PMID 9927333Read ↗

The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.Semantic proximity Read ↗

Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: differential phenotype of the Zac1-expressing cells during development.Semantic proximity Read ↗

Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.Semantic proximity Read ↗

Members of the <i>Plag</i> gene family are expressed in complementary and overlapping regions in the developing murine nervous systemSemantic proximity Read ↗

Zac1 Regulates an Imprinted Gene Network Critically Involved in the Control of Embryonic GrowthSemantic proximity Read ↗

Peroxisome Proliferator-Activated Receptor γ Is a Zac Target Gene Mediating Zac AntiproliferationSemantic proximity Read ↗

Zac1 functional interactions mediate AP-1 transcriptional activity.Semantic proximity Read ↗

CASZ1b, the Short Isoform of CASZ1 Gene, Coexpresses with CASZ1a during Neurogenesis and Suppresses Neuroblastoma Cell GrowthSemantic proximity Read ↗

Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitorsSemantic proximity Read ↗

<i>hZAC</i> encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancerSemantic proximity Read ↗

Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.Semantic proximity Read ↗

A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions.Semantic proximity Read ↗

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