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Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism

7 Oct 2010

Abstract excerpt

The BTBR T+tf/J inbred mouse strain displays a variety of persistent phenotypic alterations similar to those exhibited in autism spectrum disorders (ASDs). The unique genetic background of the BTBR strain is thought to underlie its lack of reciprocal social interactions, elevated repetitive self-directed grooming, and restricted exploratory behaviors. In order to clarify the existence, range, and mechanisms of...

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PMID: 21040460
DOI: 10.1111/j.1601-183x.2010.00659.x

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