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Article

A Transcriptional Program Mediating Entry into Cellular Quiescence

4 Jun 2007

Abstract excerpt

The balance of quiescence and cell division is critical for tissue homeostasis and organismal health. Serum stimulation of fibroblasts is well studied as a classic model of entry into the cell division cycle, but the induction of cellular quiescence, such as by serum deprivation (SD), is much less understood. Here we show that SS and SD activate distinct early transcriptional responses genome-wide that converge...

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PMID: 17559306
DOI: 10.1371/journal.pgen.0030091

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