Article
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Cancer cell - 13 May 2013
Cooks Tomer, Pateras Ioannis S, Tarcic Ohad, Solomon Hilla, Schetter Aaron J, Wilder Sylvia, Lozano Guillermina, Pikarsky Eli, Forshew Tim, Rosenfeld Nitzan, Rozenfeld Nitzan, Harpaz Noam, Itzkowitz Steven, Harris Curtis C, Rotter Varda, Gorgoulis Vassilis G, Oren Moshe
Abstract excerpt
The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53 (mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms. We report that mutp53 prolongs TNF-α-induced NF-κB activation in cultured cells and intestinal organoid cultures. Remarkably, when exposed to dextran sulfate sodium, mice harboring a germline p53 mutation develop severe chronic inflammation and...
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