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Article

IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor

6 Jun 2007

Abstract excerpt

Choriocarcinoma is a highly malignant tumor that can arise from trophoblasts of any type of gestational event but most often from complete hydatidiform mole. IGF-II plays a fundamental role in placental development and may play a role in gestational trophoblastic diseases. Several studies have shown that IGF-II is expressed at high levels in hydatidiform moles and choriocarcinoma tissues; however, conflicting...

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PMID: 17556377
DOI: 10.1093/molehr/gam039

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