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Stimulation of Human Extravillous Trophoblast Migration by IGF-II Is Mediated by IGF Type 2 Receptor Involving Inhibitory G Protein(s) and Phosphorylation of MAPK

1 Aug 2001

Abstract excerpt

We have earlier shown that migration and invasiveness of first trimester human extravillous trophoblast cells are stimulated by IGF-II, independently of IGF type 1 receptor and that migration stimulation is the primary reason for increased extravillous trophoblast cell invasiveness induced by IGF-II. In the present study we examined the functional role of IGF type II receptor in IGF-II stimulation of extravillous...

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PMID: 11502794
DOI: 10.1210/jcem.86.8.7711

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