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Role of the IGF system in trophoblast invasion and pre-eclampsia

1 Dec 1999

Abstract excerpt

Insulin-like growth factor-II (IGF-II) and IGF binding protein-1 (IGFBP-1) appear to play an important role in paracrine interactions at the maternal-fetal interface in human pregnancy. Patterns of expression of IGF-II and IGFBP-1 at the decidual-trophoblast interface suggest paracrine interactions occur between the IGF-II-expressing invading cytotrophoblast and maternal decidua-derived IGFBP-1....

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PMID: 10690804
DOI: 10.1093/humrep/14.suppl_2.90

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