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Article

A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression.

Traffic (Copenhagen, Denmark) - 1 Sept 2007

Yuseff María Isabel, Farfan Pamela, Bu Guojun, Marzolo María-Paz

Abstract excerpt

Megalin is a large endocytic receptor expressed at the apical surface of several absorptive epithelia. It binds multiple ligands including apolipoproteins, vitamin and hormone carrier proteins and signaling molecules such as parathyroid hormone and the morphogen sonic hedgehog. An important characteristic of megalin is its high endocytic activity, which is mediated by tyrosine-based endocytic motifs within the...

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Identifiers

PMID: 17555532
DOI: 10.1111/j.1600-0854.2007.00601.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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