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Article

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.

Science (New York, N.Y.) - 1 Jun 2012

Tagliabracci Vincent S, Engel James L, Wen Jianzhong, Wiley Sandra E, Worby Carolyn A, Kinch Lisa N, Xiao Junyu, Grishin Nick V, Dixon Jack E

Abstract excerpt

Protein phosphorylation is a fundamental mechanism regulating nearly every aspect of cellular life. Several secreted proteins are phosphorylated, but the kinases responsible are unknown. We identified a family of atypical protein kinases that localize within the Golgi apparatus and are secreted. Fam20C appears to be the Golgi casein kinase that phosphorylates secretory pathway proteins within S-x-E motifs. Fam20C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22582013
DOI: 10.1126/science.1217817
PMCID: PMC3754843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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