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Article

Differential phosphorylation signals control endocytosis of GPR15.

Molecular biology of the cell - 15 Aug 2017

Okamoto Yukari, Shikano Sojin

Abstract excerpt

GPR15 is an orphan G protein-coupled receptor (GPCR) that serves for an HIV coreceptor and was also recently found as a novel homing receptor for T-cells implicated in colitis. We show that GPR15 undergoes a constitutive endocytosis in the absence of ligand. The endocytosis was clathrin dependent and partially dependent on β-arrestin in HEK293 cells, and nearly half of the internalized GPR15 receptors were...

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Identifiers

PMID: 28615320
DOI: 10.1091/mbc.E16-09-0627
PMCID: PMC5555655

Genes

GPR15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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