Article
In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.
Human molecular genetics - 15 Jun 2010
Qu Hui-Qi, Bradfield Jonathan P, Li Quan, Kim Cecilia, Frackelton Edward, Grant Struan F A, Hakonarson Hakon, Polychronakos Constantin
Abstract excerpt
Recently, the Type 1 Diabetes Genetics Consortium (T1DGC) reported 22 novel type 1 diabetes (T1D)-associated loci identified by meta-analysis of three genome-wide association studies (GWASs) with a case-control design. However, the association of 10 of these 22 reported loci was not confirmed in the T1DGC family cohort (P > 0.1). To address concerns about potential bias from population stratification, this study...
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