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Article

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Nature genetics - 1 Dec 2008

Cooper Jason D, Smyth Deborah J, Smiles Adam M, Plagnol Vincent, Walker Neil M, Allen James E, Downes Kate, Barrett Jeffrey C, Healy Barry C, Mychaleckyj Josyf C, Warram James H, Todd John A

Abstract excerpt

We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci...

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Share to Diabetes Mellitus, Type 1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 18978792
DOI: 10.1038/ng.249
PMCID: PMC2635556

Genes

BACH2
CTSH
PRKCQ

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