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Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

3 Aug 2017

Abstract excerpt

Abstract Experimental CMV-based vaccine vectors expressing a single MHC class I–restricted high-avidity epitope provided strong, T cell–dependent protection against viruses or tumors. In this study we tested the low-avidity epitope KCSRNRQYL, and show that a mouse CMV (MCMV) vector provides complete immune control of recombinant vaccinia virus expressing the same epitope if KCSRNRQYL is expressed within the...

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PMID: 28768725
DOI: 10.4049/jimmunol.1602115

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