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Lentiviral vector induces high-quality memory T cells via dendritic cells transduction

10 Jun 2021

Abstract excerpt

Abstract We report a lentiviral vector harboring the human β2-microglobulin promoter, with predominant expression in immune cells and minimal proximal enhancers to improve vector safety. This lentiviral vector efficiently transduces major dendritic cell subsets in vivo. With a mycobacterial immunogen, we observed distinct functional signatures and memory phenotype in lentiviral vector- or Adenovirus type 5...

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PMID: 34112936
DOI: 10.1038/s42003-021-02251-6

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