Article
Viral MHC class I inhibition evades CD8+ T-cell effector responses in vivo but not CD8+ T-cell priming.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2012
Gainey Maria D, Rivenbark Joshua G, Cho Hyelim, Yang Liping, Yokoyama Wayne M
Abstract excerpt
Although viral MHC class I inhibition is considered a classic immune-evasion strategy, its in vivo role is largely unclear. Mutant cowpox virus lacking its MHC class I inhibitors is markedly attenuated during acute infection because of CD8(+) T-cell-dependent control, but it was not known how CD8...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.